Hua Gai San: A Classic Formula for Relieving Cough and Phlegm
- Hongji Medical
- May 23
- 4 min read
Hua Gai San comes from Bo Ji Fang (Volume 2: Treatment of the Five Organs), written by Wang Gun during the Northern Song Dynasty. This widely used Chinese herbal formula clears the lungs, relieves surface symptoms, expels phlegm, and stops cough.
It is mainly used to treat conditions caused by external wind-cold, impaired lung qi, and excessive phlegm in the body.
Throughout history, physicians have valued Hua Gai San for its ability to relieve surface cold and clear phlegm, making it a go-to formula for breathing difficulties caused by external pathogens like wind-cold or phlegm-dampness.

Formula Explanation of Hua Gai San
Hua Gai San’s herbs are organized according to the Chinese medicine principle of “monarch, minister, assistant, and envoy”:
Monarch Herb: Ma Huang. Ma Huang promotes sweating, relieves surface symptoms, opens the lungs, and eases asthma. As the primary herb, it disperses wind-cold and restores lung qi flow, relieving cough and wheezing.
Supporting Herbs: Zi Su Zi, Xing Ren.
Zi Su Zi lowers qi, clears phlegm, stops cough, and eases asthma, effectively treating cough and wheezing from phlegm obstruction.
Xing Ren stops cough, calms asthma, moistens dryness, and promotes bowel movement, helping with various coughs and wheezing. Together, they relieve cough, wheezing, and support lung qi flow.
Assistant Herbs: Sang Bai Pi, Chen Pi, Chi Fu Ling.
Sang Bai Pi clears lung heat, stops cough, and nourishes lung yin. In this formula, it helps drain lung water and prevents internal phlegm-dampness.
Chen Pi regulates qi, clears phlegm, strengthens the spleen, and stimulates appetite, smoothing qi flow and resolving phlegm to ease cough and chest tightness.
Chi Fu Ling promotes water metabolism, clears dampness, strengthens the spleen, and calms the mind, reducing phlegm by preventing internal dampness.
Envoy Herb: Zhi Gan Cao. Zhi Gan Cao (honey-fried licorice) harmonizes the formula, softens Ma Huang’s strong dispersing nature, and boosts middle qi to prevent excessive energy loss. It ensures the formula clears the lungs and expels phlegm without depleting the body.

Indications of Hua Gai San
Hua Gai San addresses conditions caused by external wind-cold, impaired lung qi, and phlegm-dampness obstruction. When wind-cold invades the lungs, it disrupts lung qi’s ability to disperse and descend, causing cough, wheezing, and chest tightness.
Phlegm-dampness worsens this, leading to excessive phlegm, nasal congestion, and hoarse voice.
Specific Indications:
Cough (heavy, with phlegm).
Wheezing (rapid breathing, difficulty breathing).
Chest tightness (feeling of fullness or discomfort).
Cold or stiff shoulders and back.
Hoarse or heavy voice.
Nasal congestion.
Dizziness or blurred vision.
Excessive phlegm.
Symptoms like wheezing with clear, white phlegm, chest discomfort, nasal congestion, hoarse voice, aversion to cold, fever, white greasy tongue coating, and a floating, tight pulse.

Effects of Hua Gai San
Hua Gai San clears the lungs, relieves surface symptoms, lowers qi, and expels phlegm to restore normal lung function and relieve symptoms. It also targets internal phlegm-dampness and qi stagnation, which cause cough, excessive phlegm, and chest tightness.
By dispersing wind-cold and clearing phlegm, herbs like Ma Huang, Zi Su Zi, and Xing Ren smooth qi flow and resolve phlegm obstruction, treating and preventing lung-related issues.
Main Effects:
Clear Lungs and Relieve Surface: Ma Huang promotes sweating and opens the lungs, clearing wind-cold and relieving cough and wheezing.
Lower Qi and Clear Phlegm: Zi Su Zi and Xing Ren lower qi, expel phlegm, and stop cough, addressing phlegm-related cough and wheezing.
Clear Lung Heat and Stop Cough: Sang Bai Pi clears lung heat, stops cough, and prevents phlegm buildup.
Regulate Qi and Clear Phlegm: Chen Pi smooths qi and resolves phlegm, easing cough and chest tightness.
Promote Water Metabolism: Chi Fu Ling clears dampness and reduces phlegm production.
Harmonize Formula: Zhi Gan Cao balances the herbs and prevents excessive energy loss.

Modern Applications
Modern research highlights Hua Gai San’s antibacterial, anti-inflammatory, digestive, antispasmodic, pain-relieving, and antioxidant properties, making it effective for various respiratory conditions, including colds, whooping cough, chronic laryngitis, tracheitis, pneumonia, tuberculosis, chronic rhinitis, myocarditis, pericarditis, emphysema, bronchitis, nasal polyps, hypertensive kidney disease, hypertensive heart disease, and tricuspid valve issues.
Clinically, it is widely used for respiratory conditions like chronic bronchitis, acute asthma attacks, and pulmonary fibrosis. Patients often see significant relief from cough, wheezing, chest tightness, and nasal congestion.
For colds, whooping cough, and chronic laryngitis, it reduces throat pain and cough. It also improves symptoms in pneumonia, tuberculosis, and chronic rhinitis.
When combined with other formulas, Hua Gai San shows strong results in treating respiratory issues.
Precautions
When using Hua Gai San, consider these points:
Avoid in Phlegm-Heat Cough: Despite Sang Bai Pi’s cooling nature, the formula is warming overall, so it’s unsuitable for cough with phlegm-heat.
Individual Differences: Adjust the formula based on the patient’s constitution, under professional guidance.
Adjustments: Tailor to symptoms. For strong cold with fever and chills, add Gui Zhi or Sheng Jiang to enhance surface relief. For heavy phlegm, add Ban Xia or Bai Jie Zi to clear phlegm. For severe wheezing, add Su Ye or Qian Hu to relieve asthma. For frequent cough with itchy throat, add Bai Bu or Jie Geng to soothe the lungs.
Conclusion
Hua Gai San is a versatile Chinese herbal formula, ideal for treating wind-cold invasion, impaired lung qi, and excessive phlegm. By clearing the lungs, expelling phlegm, and stopping cough, it effectively relieves cough, wheezing, chest tightness, and nasal congestion, restoring lung function. Its wide use in modern medicine for respiratory conditions highlights its clinical value and lasting relevance.