Gui Zhi Jia Long Gu Mu Li Tang: A TCM Formula for Heart Yang Deficiency
- Hongji Medical 
- Jun 2
- 4 min read
Gui Zhi Jia Long Gu Mu Li Tang, or Cinnamon Twig Plus Dragon Bone and Oyster Shell Decoction, is a classic formula from the Treatise on Cold Damage (Shanghan Lun) by Zhang Zhongjing.
This revered Traditional Chinese Medicine (TCM) remedy is designed to warm and tonify heart yang while calming the mind and relieving palpitations. It treats heart yang deficiency, with symptoms like irritability, palpitations, insomnia, chest tightness, cold limbs, shortness of breath, spontaneous sweating, pale complexion, a pale tongue with white coating, and a slow, weak pulse. The formula’s simple yet effective blend of herbs works synergistically to restore balance.

Formula Composition and Roles
Gui Zhi Jia Long Gu Mu Li Tang is composed of herbs organized according to the TCM principle of “monarch, minister, assistant, and envoy”:
- Monarch: Cinnamon Twig (Gui Zhi)Cinnamon Twig, pungent and sweet with a warm nature, is the primary herb. It warms heart yang, invigorates heart function, and promotes blood circulation, addressing the core issue of heart yang deficiency and improving blood flow to relieve symptoms. 
- Minister: Licorice (Gan Cao)Licorice plays a dual role: it tonifies heart qi, working with Cinnamon Twig to warm and restore heart yang, and strengthens spleen qi to support qi and blood production, addressing the root of deficiency. 
- Assistants: Dragon Bone (Long Gu) and Oyster Shell (Mu Li)These herbs have a heavy, calming effect, stabilizing the mind and relieving palpitations. They address irritability, palpitations, and insomnia by anchoring the unsettled spirit caused by heart yang deficiency. 
- Envoy: None explicitly designated, though Licorice also harmonizes the formula, ensuring the herbs work together effectively. 

Pathophysiology
The formula targets three key pathological mechanisms:
- Heart Yang DeficiencyHeart yang deficiency occurs when the heart’s warming and propelling energy is weak, impairing its ability to circulate blood and warm the body. This leads to symptoms like cold limbs, shortness of breath, spontaneous sweating, pale complexion, a pale tongue with white coating, and a slow, weak pulse. It also affects the mind, causing irritability, palpitations, and insomnia. 
- Unsettled Spirit (Heart Shen Disturbance)A deficient heart yang fails to anchor the spirit, leading to a “floating” heart shen. This causes emotional unrest, manifesting as irritability, palpitations, and insomnia. 
- Impaired Blood CirculationWeak heart yang hinders blood flow, causing stagnation and symptoms like chest tightness, pale complexion, and a weak pulse. Poor circulation further exacerbates heart yang deficiency. 
Indications and Benefits
Gui Zhi Jia Long Gu Mu Li Tang is primarily used for heart yang deficiency, with symptoms including:
- Irritability and restlessness 
- Palpitations 
- Insomnia 
- Chest tightness 
- Cold limbs 
- Shortness of breath 
- Spontaneous sweating 
- Pale complexion 
- Pale tongue with white coating 
- Slow, weak pulse 
The formula’s main benefits are:
- Warming Heart Yang: Cinnamon Twig invigorates heart yang to relieve symptoms of deficiency. 
- Calming the Mind and Relieving Palpitations: Dragon Bone and Oyster Shell anchor the spirit, easing irritability, palpitations, and insomnia. 
- Promoting Blood Circulation: Cinnamon Twig improves blood flow to address stagnation. 
- Tonifying Heart Qi: Licorice strengthens heart function, reducing palpitations and shortness of breath. 
- Strengthening Spleen Qi: Licorice supports the spleen to enhance qi and blood production, addressing the root of deficiency. 
Modern Applications of Gui Zhi Jia Long Gu Mu Li Tang
Modern research highlights the formula’s effectiveness in treating heart and neurological conditions, including:
- Anti-arrhythmic Effects: It regulates heart rhythm in conditions like tachycardia, bradycardia, premature beats, and sick sinus syndrome. 
- Improved Heart Function: It enhances cardiac pumping in heart failure patients. 
- Calming Effects: It soothes the nervous system, alleviating anxiety and insomnia. 
Clinically, it is used for:
- Arrhythmias: Regulates heart rhythm and improves cardiac function. 
- Heart Failure: Strengthens heart pumping and circulation. 
- Neurosis: Calms irritability, palpitations, and insomnia in conditions like anxiety or stress-related disorders. 
Patients often report significant relief from palpitations, shortness of breath, insomnia, irritability, and chest tightness after using this formula.
Precautions for Use
When using Gui Zhi Jia Long Gu Mu Li Tang, consider the following:
- Pattern Differentiation: The formula is specific to heart yang deficiency. A TCM practitioner must confirm the diagnosis to ensure suitability. 
- Individual Variations: Adjust the formula based on the patient’s constitution, under professional guidance. 
- Modifications: For severe shortness of breath or sweating, add Astragalus (Huang Qi) to boost qi and stabilize the exterior. For pronounced palpitations or insomnia, add Sour Jujube Seed (Suan Zao Ren) or Arborvitae Seed (Bai Zi Ren) to enhance calming effects. 
- Contraindications: Avoid in patients with heart yin deficiency or blood deficiency, as the warming nature may worsen these conditions. 
Conclusion
Gui Zhi Jia Long Gu Mu Li Tang is a time-honored TCM formula that effectively treats heart yang deficiency with its blend of warming, tonifying, and calming herbs. By warming heart yang, promoting circulation, and soothing the mind, it relieves symptoms like palpitations, insomnia, and chest tightness.
Its modern applications in cardiac and neurological conditions highlight its enduring value. Always consult a qualified TCM practitioner to ensure proper diagnosis and safe use, tailored to individual needs. This formula’s historical significance and therapeutic potential continue to support patient well-being.




